METHOD FOR THE PREPARATION OF DROSPYRENON (6 BETA,7 BETA: 15 BETA,16 BETA - DIMETHYLENE-3-OXO-17 ALPHA -PREGN-4-ENE-21,17-CARBOLACTON, DRSP)AS WELL AS 7 ALPHA-(3-HYDROXY-1-PROPYL)-(6 BETA,7 BETA: 15 BETA,16 BETA -DIRMETHYLENE-5 BETA-ANDROSTAN-3 BETA,5,17 BETA -TRIOL (ZK 92836) AND (6 BETA,7 BETA: 15 BETA,16 BETA - DIMETHYLENE-5 BETA-HYDROXY-3-OXO-17 ALPHA -ANDROSTAN-21, 17-CARBOLACTON (90965) AS INTERMEDIATE COMPOUNDS OF THE METHOD

摘要

The invention relates to a method for the preparation ofdrospirenon (6,78: 15,16 -dimethylene-3-oxo-17-pregn-4-ene-21,17-carbolacton DRSP)as well as of 7 -(3-hydroxy-1-propyl)-(6,7: 15,16 -dimethylene-5-androstan-3, 5, 17 - triol (ZK 92836) and (6,7:15,16 -dimethylene-5-hydroxy-3-oxo-17 -anddrostan-21,17-carbolacton (ZK90965) which are used as intermediatecompounds for its application.5 claims