Processes for synthesizing (1s, 2R) indandiol to synthesize (1s) amino (2R) indanol substantially free of any estereoisômero bio resolution to remove the CIS (1s,2R) indandiol a mixture of CIS (1s, 2R

摘要

A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of the enzyme dioxygenase, followed by various chemical step(s), e.g., chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.