Method to increase the effectiveness of an antifungal compound used to treat a fungal infection Method to treat a fungal infection Pharmaceutical composition and method to control the growth of a fungal organism on a substrate to be inserted into the body

摘要

A method for increasing the effectiveness of an anti-fungal compound is described. In the method, an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof are administered to a mammal in a combined amount effective to treat a fungal infection. The N-alkyl heterocyclic compound or salt thereof is present in an amount effective to potentiate or increase the anti-fungal activity of the anti-fungal compound. The N-alkyl heterocyclic compound has the formula: The variable "n" ranges from 5 to 17, and the heterocyclic ring defined by is a substituted or unsubstituted ring having four to eight members. A pharmaceutical composition is described where the anti-fungal compound and the N-alkyl heterocyclic compound or salt thereof are present in a combined amount effective to treat a fungal infection. A method for controlling the growth of fungal organisms on various substrates to be inserted into the body using a combined amount of an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof is also described.