PROCESS OF OBTAINING VERY PURE CYCLOSPORIN A AND RELATED CYCLOSPORINS BY CHROMATOGRAPHY

摘要

The present invention relates to a novel chromatographic process, which is suitable for the purification of cyclosporin-containing crude extracts on industrial scale. In this process, the conventional preparative chromatographic separation methods are completely or at least partially replaced by the Simulated Moving Bed method (SMB). The cyclosporin A obtained in the above-described process satisfies the quality requirements.