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Soluble fusion molecules with binding specificity for leukocyte adhesion molecule cd11a/cd18
Soluble fusion molecules with binding specificity for leukocyte adhesion molecule cd11a/cd18
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机译:对白细胞粘附分子cd11a / cd18具有结合特异性的可溶性融合分子
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摘要
Soluble fusion molecules were prepared which contained a CD11a/CD18 specific binding region operatively linked to an immunoglobulin constant region. These molecules particularly include extracellular portions of adhesion molecules such as ICAM-1 and ICAM-2 attached to IgG constant regions. The fusion molecules described are utilized as costimulatory agents for the activation of T cells and in methods for increasing CD4+ T cell proliferative response and IL-2 induction.
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