首页>
外国专利>
Sulfonamidsubstituerte forbindelser, fremgangsmÕter for deres fremstilling, deres anvendelse som medikament eller diagnostikum, samt medikament inneholdende forbindelsen
Sulfonamidsubstituerte forbindelser, fremgangsmÕter for deres fremstilling, deres anvendelse som medikament eller diagnostikum, samt medikament inneholdende forbindelsen
展开▼
机译:磺酰胺取代的化合物,其制备方法,作为药物或诊断剂的用途以及含有该化合物的药物
展开▼
页面导航
摘要
著录项
相似文献
摘要
Pyranopyridine derivatives of formula (I) and their salts are new. R1, R2 = H, CF3, C2F5, C3F7, 1-6C alkyl or phenyl (optionally substituted by 1 or 2 F, Cl, Br, I, CF3, CH3, OCH3, sulphamoyl or methanesulphonyl); or R1+R2 = 2-10C alkylene (with one CH2 group optionally replaced by O, CO, S, SO, SO2 or NR10); R10 = H or 1-3C alkyl; R3 = R12-CaH2aÄNR13)Üm-; R12 = H, 3-8C cycloalkyl, CF3, C2H5 or C3H7; a = 0-10; m = 0 or 1; R13 = H or 1-6C alkyl; or R12+R13 = 4-8C alkylene (with one CH2 group optionally replaced by O, S, SO, SO2, CO or NR10); R4 = R14-CrH2r-; r = 0-20; R14 = H, 3-8C cycloalkyl, piperidyl, 1-pyrrolidinyl, N-morpholino, N-methylpiperazino, CF3, C2H5, C3H7, pyridyl, thienyl, imidazolyl or phenyl (optionally substituted by 1 or 2 F, Cl, Br, I, CF3, CH3, OCH3, sulphamoyl, methanesulphonyl or methanesulphonylamino); one CH2 group in CrH2r may be replaced by O, CH=CH, CC, CO, COO, OCO, CO-R11, S, SO, SO2 or NR11; or R3+R4 = 3-8C alkylene (with one CH2 group optionally replaced by O, S, SO, SO2, CO or NR11); R11 = H or -(CaH2a)-R10 (with one CH2 group optionally replaced by O, CH=CH, CC, CO, COO, OCO, S, SO, SO2, NR10 or CONR10); R5+R6 = -CR15=CR16-CR17=N-, -CR15=CR16-N=CR17-, -CR15=N-CR17=N-, -CR15=N-N=CR17-, -N=CR16-CR17=N- or -S-CR15=CR16; R15, R16, R17 = H, F, Cl, Br, I, 1-4C alkyl, 3-8C cycloalkyl, CN, CF3, C2H5, C3H7, NO2, CONR19R21, COOR21, R22-CsH2s-Z or phenyl (optionally substituted by 1 or 2 F, Cl, Br, I, CF3, CH3, OCH3, sulphamoyl or methanesulphonyl); R21 = H, methyl, ethyl, phenyl (optionally substituted by 1 or 2 F, Cl, Br, I, CF3, CH3, OCH3, sulphamoyl or methanesulphonyl) or CuH2uNR19R20 ; R19, R20 = H or 1-3C alkyl; u = 2 or 3; R22 = H, 3-8C cycloalkyl, COOR21, CONR19R21, thienyl, imidazolyl, pyridyl, quinolyl, isoquinolyl, piperidyl, 1-pyrrolidinyl, N-morpholino, N-methylpiperazino, CF3, C2H5, C3H7 or phenyl (optionally substituted by 1 or 2 F, Cl, Br, I, CF3, CH3, OCH3, sulphamoyl or methanesulphonyl); s = 0-6; Z = S, SO, SO2, CO, S-NR11, SO-NR11, SO2-NR11, SO2-O, O, NR11 or CO-NR11; R7 = H, OH, 1-4C alkoxy, 1-4C acyloxy, Cl, Br, F or 1-4C alkyl; and R8 = H or 1-6C alkyl.
展开▼