PRODUCTION OF IMMUNOGENIC CONSTRUCTS USING ORGANIC CYANYLATING REAGENTS TO ACTIVATE CARBOHYDRATES AND THEN COUPLING THE CARBOHYDRATE TO A PROTEIN, PEPTIDE OR HAPTEN

摘要

The invention relates to a process for producing an immunogenic construct comprising activating at least one first carbohydrate-containing moiety with CDAP, and covalently joining the activated first moiety to a second moiety. Preferably, the first moiety is a polysaccharide and the second moiety is a protein. Immunogenic constructs are prepared by this process using either direct or indirect conjugation of the first and second moieties.