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CONTROLLED RELEASE FORMULATIONS CONTAINING A POORLY SOLUBLE DRUG IN A SOLID DISPERSION WITH A HYDROPHILIC POLOXAMER
CONTROLLED RELEASE FORMULATIONS CONTAINING A POORLY SOLUBLE DRUG IN A SOLID DISPERSION WITH A HYDROPHILIC POLOXAMER
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机译:含亲水性泊洛沙姆固体分散体中含有难溶药物的受控释放剂型
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摘要
A controlled release formulation for oral administration comprises a solid dispersion of a poorly soluble active ingredient in a hydrophilic poloxamer, the solid dispersion being a component of a core and the core as such or following coating of the core with a polymeric coating being effective to achieve therapeutic levels of the active ingredient over extended periods of time (24 hours or longer) following oral administration. The formulation can be in a multi-particulate form such as pellets or mini-tablets or in the form of tablets. Examples of active ingredients whose solubility and therapeutic effectiveness can be improved with the formulation are cisapride, cyclosporin, diclofenac, felodipine, ibuprofen, indomethacin, nicardipine, nifedipine, terfenadine and theophylline.
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