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TIE-2 RECEPTOR LIGANDS (LIGAND-3 TIE; LIGAND-4 TIE) AND THEIR APPLICATION
TIE-2 RECEPTOR LIGANDS (LIGAND-3 TIE; LIGAND-4 TIE) AND THEIR APPLICATION
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机译:TIE-2受体配体(LIGAND-3领带; LIGAND-4领带)及其应用
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摘要
The present invention provides for an isolated nucleic acid molecule encoding TIE ligand-3 or TIE ligand-4. In addition, the invention provides for a receptorbody which specifically binds TIE ligand-3 or TIE ligand-4. The invention also provides an antibody which specifically binds TIE ligand-3 or TIE ligand-4. The invention further provides for an antagonist of TIE. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE receptor, a method of blocking the growth or differentiation of a cell expressing the TIE receptor and a method of attenuating or preventing tumor growth in a human.
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