首页>
外国专利>
AROMATIC BICYCLE COMPOUNDS AND THEIR APPLICATION IN HUMAN AND VETERINARY MEDICINE AS WELL AS IN COSMETOLOGY
AROMATIC BICYCLE COMPOUNDS AND THEIR APPLICATION IN HUMAN AND VETERINARY MEDICINE AS WELL AS IN COSMETOLOGY
展开▼
机译:芳香族自行车化合物及其在人,兽药以及美容方面的应用
展开▼
页面导航
摘要
著录项
相似文献
摘要
Bicyclic-aromatic derivatives (I) are new. Bicyclic-aromatic derivatives of formula (I), their optical and geometrical isomers and their salts are new: R1 = methyl, -CH2OR2 or -CO-R3; Ar1 = a group of formula (a)-(c): Ar2 = furyl, thienyl, pyridinyl or a group of formula (d) or (e): X = a group of formula (f)-(i): R2 = H, lower alkyl or -CO-R16; R3 = H, lower alkyl, -NR''R' or -OR17; R4,R5,R7 = H, polyether, lower alkyl or -OR18; R6 = tert.butyl; R6 + R7 = 6-membered ring (optionally substituted by methyl and/or optionally including S or O); R8 = tert.butyl, adamantyl, aryl or aralkyl; R9 + R10 = 5-6 membered ring (optionally substituted by methyl and/or optionally including S or O); R11 = H, 1-9C alkyl, OH, alkoxy, polyether or -OR19; R12 = H, OH, alkoxy, polyether or -OR19; R13 = H, lower alkyl or -COR20; Y = O or -CH2-; R16, R20 = lower alkyl; R17 = H, 1-20C alkyl, alkenyl, mono- or polyhydroxyalkyl, aryl, aralkyl (optionally substituted) or a sugar; R', R'' = H, lower alkyl, mono- or polyhydroxyalkyl, aryl (optionally substituted) or amino acid; R' + R'' = heterocyclic ring; R18 = H, lower alkyl or R19; R19 = alkenyl, mono- or polyhydroxyalkyl, aryl, aralkyl (optionally substituted) or -(CH2)n-R21; R21 = heterocyclic ring, monohydroxyalkyl, thiol (optionally substituted by one lower alkyl), amino (optionally substituted by at least one lower alkyl), -COOR22 or -CON(R23)R24; R14, R15, R22 = H or lower alkyl; R23, R24 = H, lower alkyl or aryl (optionally substituted); R23 + R24 = heterocyclic ring; n = 2-9; and provided that Ar1 is a group of formula (c) and X is a group of formula (f) or (g), then R11 is -OR19 or polyether, or Ar2 is a group of formula (d) with R12 being -OR19 or polyether; that R11 is methoxymethoxy on ortho position of Ar2 when Ar1 is a group of formula (c), X is a group of formula (f), R12 is H and R1 is COR3 with R3 being -OR17 and R17 being H; and that R12 is methoxymethoxy on ortho or para position of Ar1 when Ar1 is a group of formula (c), X is a group of formula (f), R11 is methyl on ortho position of Ar2 and R1 is COR3 with R3 being -OR17 and R17 being H.
展开▼