A neurotransferral factor derived from the polyuria, which is substantially purified, its method of obtaining, the sequencing of nucleoside dodecylacids, pharmaceutical compositions, processed host cells and devices which contain and use them

摘要

A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene enconding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process. IMAGE