CYCLIC AMINOPHENYLACETIC ACID DERIVATIVES WITH IMMUNOMODULATING ACTION, PROCESSES FOR PREPARATION AND SYNTHESIS INTERMEDIATES THEREOF

摘要

The invention relates to novel cyclic aminophenylacetic acid derivatives which have modulatory action on the immune reaction, to processes of preparation and intermediates in their synthesis, to therapeutic agents for autoimmune diseases, which contain these derivatives as effective ingredients, said derivatives being the general formula (I): wherein R and R are each independently a hydrogen atom or a lower alkyl group of 1 to 3 carbon atoms, R is a phenyl group which may be substituted with 1 to 3 halogen atoms, a methoxy or their combinations or a trifluoromethyl group and X indicates a hydrogen atom, a lower alkyl group, a lower alkoxy group, cyano, thiocyano, trimethylsilylethynyl group, a substituted or unsubstituted phenyl group, carbamoyl, carboxyl, lower alkoxycarbonyl, acetyl, nitro, amino, lower alkanoylamino, optionally substituted benzoylamino, optionally substituted phenylsulfonylamino, alkylthio lower alkyl, lower alkylsulfinyl, lower alkylsulfonyl or a halogen atom.