METHOD OF ENANTIOMERIC ENRICHMENT AND STEREOSELECTIVE SYNTHESIS OF CHIRAL AMINES

摘要

Amines in which the amino group is on a secondary carbon atom which is chirally substituted by R1 and R2 residuals, in which each of R1 and R2 is an alkyl or aryl group which is unsubstituted or substituted with an enzymatically non-inhibiting group and R1 is different from R2 in structure or chirality, said amines can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The transformation is carried out in the presence of an amino acceptor. Since the reaction is in an equilibrium, it can be reversed, whilst in this case it can be used for the stereoselective synthesis of one chiral form of an amine in the presence of depicted transaminase to a ketone in the presence of an amino donor.