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ARGININE ANTAGONISTS FOR INHIBITING SYSTEMIC BLOOD PRESSURE IN CONNECTION WITH NITROGEN OXIDATION OR ENDOTHELIAL DERIVED RELAXING FACTOR
ARGININE ANTAGONISTS FOR INHIBITING SYSTEMIC BLOOD PRESSURE IN CONNECTION WITH NITROGEN OXIDATION OR ENDOTHELIAL DERIVED RELAXING FACTOR
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机译:精氨酸拮抗剂可抑制与氮氧化或内皮源性松弛因子有关的系统性血液压力
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摘要
A method for prophylaxis or treatment of an animal for systemic hypotension induced by internal nitrogen oxide production. The method involves administering a therapeutically effective amount of certain arginine derivatives to inhibit nitrogen oxide formation from arginine. Preferably NG-substituted arginine or an NG,NG-disubstituted arginine (having at least one hydrogen on a terminal guanidino amino group replaced by another atomic species) is administered to an animal possibly developing or already having such induced systemic hypotension. The arginine derivatives are preferably of the L configuration and include pharmaceutically acceptable addition salts. Prophylaxis or treatment of systemic hypotension in a patient which has been induced by chemotherapeutic treatment with biologic response modifiers such as tumor necrosis factor or interleukin-2 may be accomplished. Treatment of an animal for systemic hypotension induced by endotoxin, i.e., septic shock may also be accomplished by treatment with the arginine derivatives.
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