PEPTIDES OF HUMAN PROTEIN P53 FOR USE IN HUMAN-CYTOTOXIC-T-CELL-RESPONSE-INDUCING COMPOSITIONS, AND HUMAN P53-PROTEIN-SPECIFIC T-LYMPHOCYTES

摘要

PCT No. PCT/NL93/00102 Sec. 371 Date Feb. 6, 1995 Sec. 102(e) Date Feb. 6, 1995 PCT Filed May 18, 1993 PCT Pub. No. WO93/24525 PCT Pub. Date Dec. 9, 1993A peptide comprising an amino acid sequence derived from human p53 protein, wherein said amino acid sequence has the ability to bind to a human MHC Class I molecule. Its use in prophylactic or therapeutic treatment of diseases such as human cancers showing p53 protein overexpression, and its use in induction of primary p53-specific T cells that can be used in therapeutic treatment. Its use in diagnostic tests or assays.