DERIVATIVES OF 1- (2- (SUBSTITUTED VINYL)) - 3,4-DIHYDRO-5H-2,3-BENZODIAZEPINE, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF SUCH DERIVATIVES AND COMPOSITIONS FOR THE TREATMENT OF DISORDERS OF CENTRAL NERVOUS SYSTEM.

摘要

DERIVATIVES OF 1- [2-VINYL SUBSTITUTED)] - 3,4-DIHYDRO-5H-2,3-BENZODIAZEPINE, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF SUCH DERIVATIVES AND COMPOSITIONS FOR THE TREATMENT OF SYSTEM DISORDERS CENTRAL NERVOUS. THE COMPOUNDS ACCORDING TO THE INVENTION CORRESPOND TO THE GENERAL FORMULA (I). FORMULA WHERE R REPRESENTS HYDROGEN OR ALCANOYL C1-4; R1 REPRESENTS PHENYL THAT OPTIONALLY CARRIES 1-3 IDENTICAL OR DIFFERENT SUBSTITUTES, SELECTED FROM THE GROUP CONSISTING OF HALOGEN, NITRO, AMINO, (ALKYL C1-4) AMINO, DI (ALKYL C1-4) AMINO, (ALCANOYL C1-4) , C1-4 ALKYL, C1-4 ALCOXY, METHYLENDIOXI AND HYDROXY; OR NAFTILE THAT OPTIONALLY CARRIES A SELECTED SUBSTITUTE AMONG THE GROUP CONSISTING OF HYDROXY, ALKYL C1-4 AND ALCOXI C1-4; R2 REPRESENTS HYDROGEN OR ALKYL C1-4; R3 AND R4 ARE, INDEPENDENTLY BETWEEN YES, RENT C1-4, OR R3 AND R4 TOGETHER FORM METHYLENE. THE NEW COMPOUNDS ACCORDING TO THE INVENTION AFFECT THE CENTRAL NERVOUS SYSTEM AND CAN BE USED WITH ADVANTAGE IN THERAPEUTICS.