PROCEDURE FOR THE PREPARATION ON AN INDUSTRIAL SCALE OF A HUMAN STANDARD HIGHLY PURITY FACTOR CONCENTRATE SUITABLE FOR THERAPEUTIC USE.

摘要

THE INVENTION IS RELATED TO A HUMAN VON WILLEBRAND FACTOR PREPARATION PROCEDURE FROM A Cryoprecipitated FRACTION OF PLASMA. THE PROCEDURE INCLUDES A COMBINATION OF THREE STAGES OF CHROMATOGRAPHIC SEPARATION. THE CONCENTRATE OBTAINED PRESENTS A VERY HIGH SPECIFIC ACTIVITY AND A VERY HIGH PERCENTAGE OF HIGH MOLECULAR WEIGHT MULTIMERS. THE CONCENTRATE IS INTENDED, ESPECIALLY, FOR THERAPEUTIC USE.