ARGININE ANTAGONISTS FOR INHIBITION OF SYSTEMATIC HYPOTENSION ASSOCIATED WITH THE PRODUCTION OF NITRIC OXIDE OR THE ENDOTHELIAL DERIVATIVE RELAXATION FACTOR.

摘要

A METHOD FOR THE PROPHYLAXIS OR TREATMENT OF AN ANIMAL SUFFERING FROM A SYSTEMIC HYPOTENSION INDUCED BY AN INTERNAL PRODUCTION OF NITROGEN OXIDE. THE METHOD IS TO ADMINISTER A THERAPEUTICALLY EFFECTIVE AMOUNT OF CERTAIN ARGININE DERIVATIVES TO INHIBIT THE FORMATION OF NITROGEN OXIDE FROM ARGININE. ARGININE SUBSTITUTED BY NG OR AN ARGININE SUBSTITUTED BY NG, NG (WHICH HAS AT LEAST ONE HYDROGEN IN A TERMINAL GROUP GUANIDINO AMINO SUBSTITUTED FOR OTHER ATOMIC SPECIES), MAY BE ADMINISTERED BY AN ANIMAL THAT MAY DEVELOP OCA AND AROUND AROUND. ARGININA DERIVATIVES PREFERABLY HAVE A L CONFIGURATION AND INCLUDE PHARMACEUTICALLY ACCEPTABLE ADDITIONAL SALTS. PROPHYLAXIS OR TREATMENT OF SYSTEMIC HYPOTENSION MAY BE CARRIED OUT IN A PATIENT WHO HAS BEEN INDUCED BY A CHEMOTHERAPEUTIC TREATMENT SUCH AS A TUMORAL OR INTERLEUK NECROSIS FACTOR. YOU CAN ALSO TREAT AN ANIMAL WHO SUFFERS AN ENDOTOXIN-INDUCED SYSTEMIC HYPOTENSION, TO KNOW A SEPTIC SHAKE, IF IT IS TREATED WITH ARGININE DERIVATIVES.