DNAS AND PROCESSES FOR THEIR PREPARATION, NOVEL PLASMIDS COMPRISING THEMNOVEL POLYPEPTIDES AND PROCESSES FOR THEIR PREPARATION AND NOVEL ANTI-TUMOR AGENTS COMPRISING SAID POLYPEPTIDES

摘要

Anti-tumor polypeptides represented by the aminosequence:(The amino acid sequence of TH.beta.4)-Asp-Pro-X-(the aminoacid sequence corresponding to the base sequence constructedby linking guanine with the beginning of the base sequence ofthe fourth exon of TNF-.alpha.)wherein X is a part of the linkage or represents any ofthe following amino acid sequences:1) Val-Ser-Ser-Ser-Arg-Thr-Pro-Ser-Asp-Lys-Pro-Val-Ala-His-Val-Val;2) Val-Arg-Ser-Ser-Ser-Arg-Thr-Pro-Ser-Asp-Lys-Pro-Val-Ala-His-Val-Val;3) Val-Lys-Ser-Cys-Thr-Arg-Thr-Pro-Ser-Arg-Lys-Pro-Val-Ala-His-Val-Val;4) Val-Arg-Ser-Ser-Thr-Arg-Thr-Pro-Ser-Arg-Lys-Pro-Val-Ala-His-Val-Val; and5) Val-Arg-Ser-Cys-Thr-Arg-Thr-Pro-Ser-Arg-Lys-Pro-Val-Ala-His-Val-Val;and, novel DNAs encoding them, processes for theirpreparation, and anti-tumor agents comprising them aredisclosed.