SUBSTITUTED PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE OR NEUROLOGICAL DISORDERS OF THE CENTRAL NERVOUS SYSTEM

摘要

The present invention relates to novel derivatives of a series of substitutedpyrimidines of formula (I); wherein W is O, CH2, CH2CH2, OCH2, CH2CH2CH2, or abond; R1 is a hydroxyC1-6alkyloxyC1-6alkylamino, diC1-6alkylamino (wherein thealkyl groups may be the same or different), aminoC1-6alkylamino, morpholino,piperidino, piperazino, piperazinoamino, homopiperazino, homopiperidino,homomorpholino, benzoxazino, indolino, 1,2,3,4-tetrahydroquinolino,benzylamino or anilino wherein C or N atoms may be substituted with one ormore substituents; R2 is selected from the group consisting of H; halogen; N3;OR; SR; C1-6alkyl; C6-10aryl; C6-10arylC1-6alkyl; C6-10heteroaryl; NR7R8;N=C(R11)N(R6)2; aziridino; azetidino; pyrrolidino; piperidino;hydroxypiperidino; heptamethyleneimino; piperazino; N-substituted piperazino;homopiperazino; N-substituted homopiperazino; morpholino; homomorpholine;thiomorpholino; and R12C(O)C1-6alkyl; C-substituted piperidino; X is a C6-10aryl ring or a C6-10 heteroaryl ring optionally substituted with one or moresuitable substituents for an aryl ring; R is H, C1-6alkyl, C3-8cycloalkyl, C6-10aryl or C6-10arylC1-6alkyl; provided that when -W-X is benzyl, R1 is notpiperidine; and when R1 is a hydroxyalkyloxyalkylamino, R2 is not aheterocyclic ring; and to pharmaceutical compositions which contain them, tomethods for their preparation and to their use in therapy, particularly in thetreatment of neurodegenerative or other neurological disorders of the centraland peripheral systems.