N-2-(5-BENZYLOXYCARBONYL-AMINO-6-OXO-2-(4-FLUOROPHENYL)-1,6-DIHYDRO-1-PYRIMIDINYL)ACETOXYL-L-ASPARTIC ACID ALDEHYDE AS AN IN VIVO INHIBITOR OF INTERLEUKIN-1.BETA. CONVERTING ENZYME (ICE)

摘要

This invention comprises the compound (1) and the pharmaceutically acceptablesalts thereof. Compound (1) is an interleukin-1.beta. converting enzymeinhibitor and is useful for treating inflammatory diseases such as arthritisand inflammatory bowel disease, septic shock, reperfusion injury, shigellosis,and neuroinflammatory disorders such as stroke, multiple sclerosis, andAlzheimer's disease.