Ocular therapyy in keratoconjunctivitis sicca using topically applied androgens or tgf-beta

摘要

The topical application to the ocular surface or adjacent regions of the eye of a preparation containing a therapeutically effective amount of an androgen or androgen analogue or a therapeutically effective amount of TGB- beta is disclosed as a method of relieving the chronic and acute manifestation of dry eye signs and symptoms in keratoconjunctivitis sicca (KCS), for example in Sj+E,uml o+EE gren's syndrome. Measurement of the increased tear levels of TGF- beta is disclosed as a diagnostic test to monitor the therapeutic effect of topical treatment with androgen or androgen analogues.