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Synergism between thymidine kinase gene therapy and topoisomerase i and topoisomerase ii inhibitors
Synergism between thymidine kinase gene therapy and topoisomerase i and topoisomerase ii inhibitors
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机译:胸苷激酶基因治疗与拓扑异构酶i和拓扑异构酶ii抑制剂之间的协同作用
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摘要
The invention describes a method in which adenovirus mediated thymidine kinase gene therapy enhances the sensitivity of ovarian cancer cells to topoisomerase inhibitors chemotherapy. This combination demonstrates synergistic properties. The combination is most effective when the gene therapy treatment is administered first, followed by topoisomerase inhibitor chemotherapy.
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