Nevron growth inhibitory molecules or derivatives thereof used to immunize mammals thereby promoting axon regeneration

摘要

This invention pertains to compositions comprising immunogenic agents having neuron growth inhibitory properties, which cause polyreactive antibodies to be generated that bind to axon growth inhibitors, thereby promoting axon regeneration. Said agents include myelin-associated glycoprotein (MAG), arretin or proteoglycan proteins. These compositions can be used to restore nerve transmission, particularly motor and sensory function, after spinal cord lesions or optic nerve damage. They can also be used to treat diseases involving axonal damage, such as Multiple Sclerosis and stroke. These compositions can be used further as prophylactic vaccines prior to onset of CNS disease or injury.