Combination therapy utilising 17-ketosteroids and interleukin inhibitors, or interleukin-10 potionally with interleukin inhibitors

摘要

There are provided medicaments, methods of making them, and kits, which include (1) a 17-ketosteroid compound and/or (2) an Interleukin-10 inhibitor, an Interleukin-12 inhibitor, an Interleukin-2 inhibitor, alpha-fetoprotein, or a lysosomotropic agent. Also provided are methods of treating a patient with Interleukin-10, or with Interleukin-12 and an Interleukin-10 inhibitor. There are also provided methods of treatment involving such compounds or combinations of compounds, including enhancing the TH1 immune protective response when using the 17-ketosteroid compound as an anti-viral, anti-bacterial, anti-mycoplasma or anti-intra cellular parasitic agent, and other treatments for various compounds and combinations as described.