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New 17-KDA brucella abortus antigen, recombinant polypeptides, nucleic acids coding for the same and use thereof in diagnostic and prophylactic methods and kits
New 17-KDA brucella abortus antigen, recombinant polypeptides, nucleic acids coding for the same and use thereof in diagnostic and prophylactic methods and kits
The present invention relates to an isolated 17-kDa Brucclla antigen characterized by an amino acid sequence having at least 60% homology, preferably at least 70% homology, more preferably having at least 80% homology to the amino acid sequence as shown in SEQ ID No. 1 or 2, with said antigen being specifically recognized by sera from Brucella field infected individuals, more particulary an antigen characterized by the amino acid sequence as shown in SEQ ID No. 1 or 2. The invention also relates to recombinantly produced 17 kDa Brucella antigen, nucleic acids coding for the same and the use thereof in diagnostic and prophylactic methods and kits.
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机译:本发明涉及一种分离的17-kDa Brucclla抗原,其特征在于与SEQ ID NO:1所示的氨基酸序列具有至少60%同源性,优选至少70%同源性,更优选具有至少80%同源性的氨基酸序列。 1或2,其中所述抗原被来自布鲁氏菌病感染的个体的血清特异性识别,更特别地,特征在于SEQ ID No.1或2所示氨基酸序列的抗原。本发明还涉及重组产生的17kDa布鲁氏菌抗原,编码其的核酸及其在诊断和预防方法及试剂盒中的用途。
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