This invention relates to polypeptides, nucleotide sequences, antibodies or fragments thereof, ligands and compositions and their use in the medical fields of inflammation and allergy, disease examples of which include rheumatoid arthritis and asthma. In addition the invention relates to a method for production of the polypeptides. Methods of disease treatment are suggested relying on agents developed in combination with the cloning of the human MAFA molecule. A use of the invention addresses the prevention of cell activation events in vivo which could lead to therapies for the prevention of tumour growth.
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