Use of uridine to counter 5-fluorouracil toxicity

摘要

The present invention provides a method for inhibiting pyrimidine analogue-induced toxicity in a tissue of a patient undergoing pyrimidine analogue therapy. The method comprises the step of directly contacting the tissue with a therapeutically effective amount of uridine. In one embodiment, the invention provides a method of inhibiting chemotherapy-induced stomatitis in a patient undergoing treatment with a pyrimidine analogue. The pyrimidine analogue is a chemotherapeutic agent which induces stomatitis, such as 5-fluorouracil or 5-fluoro-2'-deoxyuridine, and the tissue is an intraoral tissue, such as an oral mucosal tissue or an intraoral soft tissue.