The seizure-prone mutant rat tish displays an inherited band heterotopia modeling the human malformation of SBH. The heterotopic cells in tish rats display a variety of features that are characteristic of neocortical cells, including cellular morphology, afferent connectivity, efferent connectivity and contemporaneous neurogenesis with the neocortex. The tish rat thus represents a genetic animal model for characterizing the developmental mechanisms involved in the formation of a human-like cortical malformation, and for devising therapeutic strategies.
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