Use of fibrin sealant to maintain hemostasis, lymphostasis and prevent local accumulation of body fluids

摘要

Fibrin sealant, comprised of thrombin and fibrinogen which are mixed together and polymerized autocatalytically, is used to maintain hemostasis, lymphostasis or prevent local fluid accumulation in situations where bleeding or fluid accumulation may retard recovery, induce or aggravate pain and discomfort, or present a health risk. Fibrin sealant is employed in wound closure where a skin flap is secured to a wound perimeter, as in mastectomies, to incisions made surgically or endoscopically, in orthopedic surgery where bleeding is profuse, and in solid organ biopsies. Fibrin sealant is also effective in suppressing regrowth of surgically excised tumors. Fibrin sealant applied to the area surrounding an opening in a blood or lymphatic vessel due to catheterization is also effective in maintaining hemostasis.