LOCALIZED INTRAVASCULAR DELIVERY OF ANTIOXIDANT SUBSTANCES FOR INHIBITION OF RESTENOSIS IN RECANALIZED BLOOD VESSELS

摘要

Restenosis in re-canalized blood vessels is inhibited by an antioxidant substance, such as probucol, intramurally at a target site within the blood vessel. Usually, the antioxidant substance is delivered using a catheter having infusion ports at its distal end. Optionally, the distal end of the catheter (110) is radially expanded to engage the infusion ports directly against the blood vessel wall. Delivery of the antioxidant substance may be effected before, during, or after the re-canalization procedure.