LCK SERINE PHOSPHORYLATION ASSAY FOR T-CELL ACTIVATION AND ACTIVATION-INDUCED CELL DEATH

摘要

The invention features an assay which allows the correlation between the ratio of serine phosphorylated lck to total lck with the level of T cell activation. This assay may be used for the rapid determination of the efficacies of therapies which either induce or prevent T cell activation. Also provided are src-family tyrosine kinase polypeptides which have reduced serine phosphorylation-mediated degradation.