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COMPOSITIONS, KITS, AND METHODS FOR EFFECTING ADENINE NUCLEOTIDE MODULATION OF DNA MISMATCH RECOGNITION PROTEINS
COMPOSITIONS, KITS, AND METHODS FOR EFFECTING ADENINE NUCLEOTIDE MODULATION OF DNA MISMATCH RECOGNITION PROTEINS
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机译:用于影响DNA错配识别蛋白的腺嘌呤核苷酸调节的组合物,试剂盒和方法
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摘要
Compositions, and products comprising a MutS homolog which binds to a mismatched region of a duplex DNA molecule in the presence of ADP are provided, as are methods of binding MutS homologs to mismatched DNA in the presence of ADP. The use of MutL homolog derivatives in combination with MutS homologs is also included. Nonhuman mammals which are nullizygous for both Msh2 and p53 are also provided, as are methods of making and using the same.
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