STROMAL CELL DERIVED FACTOR-1 (SDF-1) AND METHOD OF USE FOR DIAGNOSTIC AND PROGNOSTIC INDICATOR OF AIDS PATHOGENESIS

摘要

A nucleic acid sequence having a single nucleotide mutation in the 3' untranslated region of the mRNA transcript of the structural gene for stromal derived factor (SDF1-3'A) is provided. The mutation occured at an allele frequency of 6-26 % in various racial groups. SDF-1 is the principal ligand for CXCR4, a 7-transmembrane G-coupled receptor which, with CD4, provides an entry port for T-tropic HIV-1, a variety that frequently develops in AIDS patients just prior to CD4 T-lymphocyte depletion. Also provided in the invention is a method for determining the prognosis of a subject exposed to HIV-1 and a method for determining the susceptibility of a subject to HIV-1 infection.