2,2'-BI-1H-PYRROLE DERIVATIVES USEFUL IN THE TREATMENT OF LEUKEMIA BROUGHT ON BY HTLV-I

摘要

The use of a compound which is a 2,2'-bi-1H-pyrrole of formula (I) wherein R1 is hydrogen, phenyl, C1-C20 alkyl or C2-C20 alkenyl, wherein the alkyl and alkenyl groups are unsubstituted or substituted by 1 to 3 substituents; R2 is hydrogen, C1-C6 alkyl, cyano, carboxy or (C1-C6 alkoxy)carbonyl; R3 is halogen, hydroxy or C1-C11 alkoxy unsubstituted or substituted by phenyl; R4 represent hydrogen, C1-C6 alkyl or phenyl; each of R5 and R6, which are the same or different, independently represents hydrogen, C2-C20 alkanoyl, C3-C20 alkenoyl, phenyl, C1-C20 alkyl or C2-C20 alkenyl, wherein the alkanoyl, alkenoyl, alkyl and the alkenyl groups are unsubstituted or substituted by 1 to 3 substituents; or two of R4, R5 and R6 taken together form a C4-C12 polymethylene chain, which is unsubstituted or substituted by C1-C12 alkyl, C2-C12 alkenyl or C1-C12 alkylidene; or pharmaceutically acceptable salt thereof; in the preparation of a medicament for use in the treatment of adult-T-cell leukemia-lymphoma, in particular brought on by infection with HTLV-I.