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USE OF DIPEPTIDYL PEPTIDASE (DPP4) OF FIBROBLAST ACTIVATING PROTEIN ALPHA FOR SUPPRESSING THE MALIGNANT PHENOTYPE OF CANCER CELLS
USE OF DIPEPTIDYL PEPTIDASE (DPP4) OF FIBROBLAST ACTIVATING PROTEIN ALPHA FOR SUPPRESSING THE MALIGNANT PHENOTYPE OF CANCER CELLS
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机译:使用成纤维细胞活化蛋白α的二肽肽酶(DPP4)抑制癌细胞的恶性表型
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摘要
This invention provides a method of suppressing the malignant phenotype or inducing apoptosis of cancer cells in a subject, comprising introducing into the cancer cell an amount of a nucleic acid encoding a dipeptidyl peptidase IV protein or fibroblast activating protein-α, thereby suppressing the malignant phenotype of the cancer. This invention provides a method of treating a subject with cancer which comprises administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a purified dipeptidyl peptidase IV protein or fibroblast activating protein-α and a pharmaceutical acceptable carrier or diluent. This invention provides a method of inducing expression of dipeptidyl peptidase IV or fibroblast activating protein-α in cancer cells of a subject, comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of an agent capable of activating transcription of the dipeptidyl peptidase IV gene or fibroblast activating protein-α and a pharmaceutical acceptable carrier or diluent.
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