Pharmaceutical preparation with factor VIII procoagulant activity and vWF-binding activity

摘要

Novel stable pharmaceutical preparation (A) contains a protein (I), with factor VIII procoagulant and von Willebrand factor (vWF) binding activities, which has an amino acid sequence derived from factor VIII but includes a mutation in at least 1 immunodominant region. Also new are: (1) biologically active factor VIII complex, containing (I) and vWF; and (2) antibodies (Ab) specific for (I).