A catheter (1) for retro-perfusion of myocardium has an infusion tip (12), such that when retro-perfusing myocardium (64), the tip (12) extends within the coronary sinus (86) to a depth in a range of about 2 inches to 4 inches (5 cm to 10 cm) from the coronary sinus ostium (88). The catheter (1) also comprises a tube (10) defining at least three channels. The channels include an infusion channel (22), which has a first infusion end coupled to an infusion port (14) located in the infusion tip (12) and a second infusion end coupled to an outlet orifice (24b) of a pump (24); a withdrawal channel (20) which has a first withdrawal end coupled to a withdrawal port (16) located in the superior vena cava (82) and a second withdrawal end coupled to an inlet orifice (24a) of the pump (24); and a pressure monitoring channel for monitoring pressure at pressure port at the infusion tip (12) having a first monitoring end coupled to the pressure port and a second monitoring end coupled to a pressure sensor (30). The catheter also has a microprocessor for controlling the pump and measuring a rate of retro-perfusate flow.
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