METHODS AND COMPOSITIONS FOR SUPPRESSING AN IMMUNE RESPONSE USING MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS II PEPTIDES

摘要

Methods and compositions for suppressing an immune response using or comprising peptide fragments of the alpha chain of class II major histocompatibility complex containing a highly conserved motif and effective to suppress at least one and preferably all of the following: a mixed lymphocyte reaction or other T-cell allorecognition reaction; generation of cytotoxic T-cells recognizing an alloantigen; lymphocyte proliferation against tissue antigen; and stimulatory cytokine production by lymphocytes. Immune responses that can be abated or suppressed include alloimmunity and autoimmunity.