Cancer cell death using specific promoters and genes (IV)

摘要

The present invention relates to a method for expressing thymidine kinase (TK) of Herpes Simplex Virus (HSV) using a specific promoter that is expressed only in a specific cancer cell, and then the expressed TK phosphorylates Gancyclovir, It is possible to kill cancer cells by inhibiting them, or to induce apoptosis and to induce apoptosis by killing cancer cells without affecting other normal cells by the action of a promoter specifically expressed in cancer cells .;Specific promoters include the prostate-specific antigen (PSA), vascular endothelial growth factor (VEGF), chorionic gonadotropin (hCG), carcinoembryonic antigen (CEA), and alpha fetoprotein (AFP) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), such as the thymidine kinase (TK) gene, or interleukin-1 (IL-1) converting enzyme (ICE) .