A process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-(5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy-acetamide using an aprotic, aromatic solvent

摘要

The present invention relates to a process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-trifluoromethyl)-1,3,4-thiadazol-2-yl)-oxy]-acetamide in an aprotic, aromatic solvent. The process includes the stepps of: (a) reacting 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole with N-(4-fluorophenyl)-N-(1-methylethyl)-2-hydroxyacetamide and an aqueous alkali in the presence of an aprotic, aromatic solvent to form an aqueous phase and an organic phase; (b) acidifying the phases, (c) separating the phases; and (d) recovering the N-(4-fluorophenyl)-N-(1-methylethyl)-2-[(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-oxy]-acetamide from the organic phase.