Scid mouse having a normal immun response to exogenous antigens

摘要

An immunodeficient mammal, e.g. a mouse, having engrafted human lymphocytes which retain the ability to show a normal human immune response. The human lymphocytes in these mammals, e.g. mice, no longer have a xeno-response of the human lymphocytes but do have the ability to respond to exogenous antigens, essentially from the time of engrafting of the human lymphocytes into the mice. This has resulted in an animal model that is able to test the efficacy of human immunotherapeutic protocols. Further, by combining the xenotolerant human lymphocytes (huPBL) with human tumors, human anti-tumor immunity can be monitored. The invention also includes the method of using the mammal to test human immune response.