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Improved in vitro method, kits and reagents for screening for blood coagulation defects
Improved in vitro method, kits and reagents for screening for blood coagulation defects
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机译:改进的体外方法,试剂盒和试剂,用于筛查凝血功能缺陷
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摘要
In vitro photometric method for qualitative screening and quantitative determination of the functional activity of components of the Protein C anti-coagulant pathway of blood coagulation, comprising measuring the conversion rate of an exogenous substrate by an enzyme, the activity of which is related to the Protein C anticoagulant activity, in a blood sample of a human comprising coagulation factors and said exogenous substrate after at least partial activation of coagulation through the intrinsic, extrinsic or common pathway and triggering coagulation by adding calcium ions; and comparing said conversion rate with the conversion rate of a normal human blood sample determined in the same way, comprising adding further metal(s) ions to said sample; kits and reagents for use in said method.
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