Shock proteins of the HSP70 family derived from Streptococcus sp.

摘要

A novel heat shock of Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus agalactiae, which are a type of HSP70 family with an apparent molecular weight of 70-72 kilodaltons protein; Immunologically related polypeptides; The amino acid sequence of HSP70 (SEQ ID NO: 4; SEQ ID NO: 5) on the nucleotide and derived S. pneumoniae; Amino acid sequence of the nucleotide and the derived S. Paganense HSP70 (SEQ ID NO: 19; SEQ ID NO: 20); Amino acid sequence of HSP70 (SEQ ID NO: 21; SEQ ID NO: 22) in nucleotides and derived S. agalactia; Recombinant DNA methods for the production of SP70 / HSP72 and immunologically related proteins; And antibodies that bind to these HSP's.;The polypeptides, amino acid sequences and antibodies according to the present invention provide a method for the diagnosis, prevention and treatment of diseases caused by S. pneumoniae and other related bacteria such as S. guinegans and S. agalactiae .