Novel azepan and its cyclic analogs for the treatment and prevention of protein kinase mediated diseases

摘要

The compounds of formula (I), and pharmaceutically acceptable acid addition salts thereof, are protein kinase inhibitors, which can be used in the treatment of diseases mediated by the enzyme, such as inflammatory diseases and the like:;Formula I;In this formula,;R^OneIs phenyl or an alpha-or beta-naphthyl group which may be substituted by one or more substituents selected from the group consisting of hydroxy, lower alkyl, lower alkoxy, lower alkoxy-carbonyl, phenoxy, acyloxy, hydroxyphenoxy-Or an N-lower alkyl-acylamino group or the like;;R²Is phenyl or phenyl substituted with a hydroxy or acyloxy group;;Y is a carbon-carbon bond or vinylene;;n is 1, 2 or 3;