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Oncogene-or virus-regulated expression systems

机译:癌基因或病毒调节的表达系统

摘要

The present invention relates to a gene product comprising a promoter I (component a) that regulates the expression of a transcription factor gene (component b) contained in a nucleic acid construct and the gene product of the transcription factor gene (Dependent on one or more cellular regulatory proteins that specifically bind to the product and affect its activity) that are specifically bound and that regulate the expression of an operable gene (component d) contained in the nucleic acid construct (Component c), a separate cell containing said nucleic acid construct, the use of said construct for the manufacture of a medicament for the treatment of a disease, the use of said cell for the same purpose, and To a method for producing the nucleic acid construct.
机译:本发明涉及包含调节核酸构建体中所含的转录因子基因(组分b)的表达的启动子I(组分a)的基因产物和转录因子基因的基因产物(取决于一个或多个)特异性结合产物并影响其活性的细胞调节蛋白)被特异性结合并调节核酸构建体(组分c)中所含的可操作基因(组分d)的表达,所述核酸包含所述核酸构建体,所述构建体在制备用于治疗疾病的药物中的用途,所述细胞在相同目的中的用途以及制备核酸构建体的方法。

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