(E)-3-2-N-BUTYL-1-{(4-CARBOXYPHENYL)-METHYL}-1H-IMIDAZOLE-5- -YL-2-(2-THIENYL)-METHYL-2-PROPENOIC ACID METHANESULFONATE, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to (E)-3-[2-n-butyl-1-{(4-carboxyphenyl)- -methyl}-1H-imidazole-5-yl]-2-(2-thienyl)-methyl-2-propenoic acid methanesulfonate (I) which is a receptor antagonist of angiotensin-II and can be used for control over arterial hypertension caused or exacerbated by angiotensin-II and for treatment of patients with congestive cardiac and renal failure and glaucoma. Compound (I) is synthesized by treatment of (E)-3-[2-n-butyl-1-{)4-carboxyphenyl)-methyl}-1H-imidazole- -5-yl]-2-(2-thienyl)-methyl-2-propenoic acid with methanesulfonic acid in 2-propanol at 8 C. EFFECT: improved method of synthesis. 5 cl, 9 ex