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DRY METHOD FOR PREPARING PARTICLES BASED ON ACTIVE PRINCIPLES, DRY PARTICLES PREPARED BY THIS METHOD, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH PARTICLES
DRY METHOD FOR PREPARING PARTICLES BASED ON ACTIVE PRINCIPLES, DRY PARTICLES PREPARED BY THIS METHOD, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH PARTICLES
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机译:基于活性原理的干法制备颗粒,用这种方法制备的干颗粒以及包含此类颗粒的药物组合物
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摘要
FIELD: pharmaceutical industry. SUBSTANCE: invention relates to dry preparation of essentially spherical particles consisting of high-activity substance introduced into biologically compatible polymer with high boiling temperature, this polymer and above-mentioned high-activity substance being admixed under stirring to immiscible homogeneous viscous carrier. Stirring is continued until formation of biologically compatible polymer microbeads and complete introduction of high-activity substance into them are attained. Temperature of this process is not higher than vitrification temperature of polymer. EFFECT: enabled formation of microbeads with load on core material more than 15% and which have no high-activity substance on their surfaces. 16 cl, 10 ex
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