METHOD OF SYNTHESIS OF BETA-METHYLCARBAPENEM INTERMEDIATE COMPOUNDS, INTERMEDIATE COMPOUNDS

摘要

FIELD: organic chemistry, antibiotics. SUBSTANCE: invention describes a method of synthesis of the carbapenem intermediate compound of the formula (VI) where R means: (a) hydrogen atom; (b) methyl or (c) hydroxy-protective group and P′ means nitrogenous protective group; Nu means nucleophilic group taken from -CH₂CO₂--t-Bu and -SR² where R² means hydrogen atom, direct or branched C₁-C₁₀-lower alkyl, direct or branched C₂-C₁₀-alkenyl and alkynyl, C₃-C₆-cycloalkyl, C₃-C₆-cycloalkyl-C₁-C₁₀-alkyl, C₁-C₆-alkyl-C₃-C₆-cycloalkyl, aryl and aralkyl. Method of synthesis involves the interaction reaction of compound of the formula (V) where R, P′ and Nu are indicated above with weak acid in ether or ester solvent. EFFECT: universality of method of synthesis of the end compounds. 8 cl, 3 dwg, 5 ex