DERIVATIVES OF 4-QUINOLINYL SHOWING ANTI-HELICOBACTERIAL ACTIVITY, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION CONTAINING THEIR AND METHOD OF ITS PREPARING

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new derivatives of quinoline showing anti-Helicobacter activity of the formula (I) , their pharmaceutically acceptable salts with acids, their stereochemically isomeric forms, their quaternary forms and their N-oxides where A means bivalent radical of the formula: -N=CH-CH=CH- (a); -CH= N-CH= CH- (b); -N=N-CH=CH- (c); -N=CH-N=CH- (d); -N=CH-CH=N- (e); -CH= N-N= CH- (f); -N= N-N= CH- (g); -N= N-CH=N- (h); -CH=CH-CH=CH- (i); R¹,R²,R²,R⁴,R⁵ and R⁶ each independently means hydrogen, halogen atom, hydroxy-, C_1-4-alkyloxy-, C_1-4-alkyl-, trifluoromethyl-, amino-, mono- or di-(C_1-4-alkyl)-amino- or nitro-group or their pharmaceutically acceptable salts with acids, stereochemical isomeric forms, their quaternary forms or their N-oxides at condition that if one substituent at phenyl-group is a nitro-group then other substituents at the above indicated phenyl-group are distinct from nitro-group. Invention describes new compositions containing the above indicated compounds, methods of synthesis of the above indicated compounds, methods of preparing the above indicated compositions and methods of treatment of patients suffering with disorders or damages caused by Helicobacter infection. EFFECT: improved method of synthesis and preparing, enhanced effectiveness of patient treatment. 9 cl, 5 tbl, 26 ex